Characterization of human S-adenosyl-homocysteine hydrolase in vitro and identification of its potential inhibitors

• Main Authors: Weiwei Hao (Author), Yanhua Li (Author), Qiuli Shan (Author), Tian Han (Author), Wencheng Li (Author), Sheng He (Author), Kongkai Zhu (Author), Yumei Li (Author), Xiaojun Tan (Author), Jinsong Gu (Author)
• Format: Book
• Published: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Human S-adenosyl-homocysteine hydrolase (SAHH, E.C.3.3.1.1) has been considered to be an attractive target for the design of medicines to treat human disease, because of its important role in regulating biological methylation reactions to catalyse the reversible hydrolysis of S-adenosylhomocysteine...