Increased Renal Medullary NOX-4 in Female but Not Male Mice during the Early Phase of Type 1 Diabetes: Potential Role of ROS in Upregulation of TGF-β1 and Fibronectin in Collecting Duct Cells

• Main Authors: Felipe Casado-Barragán (Author), Geraldine Lazcano-Páez (Author), Paulina E. Larenas (Author), Monserrat Aguirre-Delgadillo (Author), Fernanda Olivares-Aravena (Author), Daniela Witto-Oyarce (Author), Camila Núñez-Allimant (Author), Katherin Silva (Author), Quynh My Nguyen (Author), Pilar Cárdenas (Author), Modar Kassan (Author), Alexis A. Gonzalez (Author)
• Format: Book
• Published: MDPI AG, 2023-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Chronic diabetes mellitus (DM) can lead to kidney damage associated with increased reactive oxygen species (ROS), proteinuria, and tubular damage. Altered protein expression levels of transforming growth factor-beta 1 (TGF-β1), fibronectin, and renal NADPH oxidase (NOX-4) are associated with the pro...