IL-17A Induces Hypo-contraction of Intestinal Smooth Muscle via Induction of iNOS in Muscularis Macrophages

• Main Authors: Daisuke Mori (Author), Nobumasa Watanabe (Author), Osamu Kaminuma (Author), Takahisa Murata (Author), Takachika Hiroi (Author), Hiroshi Ozaki (Author), Masatoshi Hori (Author)
• Format: Book
• Published: Elsevier, 2014-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract.: Intestinal inflammation causes disorder in bowel motility. Th17 cytokines are involved in intestinal inflammation. To understand the role of interleukin (IL)-17 in intestinal motility, we examined effects of IL-17A on contractile activities of organ-cultured ileum. Rat ileal smooth muscle...