Formononetin Upregulates Nrf2/HO-1 Signaling and Prevents Oxidative Stress, Inflammation, and Kidney Injury in Methotrexate-Induced Rats

• Main Authors: Saleem H. Aladaileh (Author), Omnia E. Hussein (Author), Mohammad H. Abukhalil (Author), Sultan A. M. Saghir (Author), May Bin-Jumah (Author), Manal A. Alfwuaires (Author), Mousa O. Germoush (Author), Amer A. Almaiman (Author), Ayman M. Mahmoud (Author)
• Format: Book
• Published: MDPI AG, 2019-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Acute kidney injury (AKI) is a serious complication of methotrexate (MTX). This study explored the protective effect of the isoflavone formononetin (FN) against MTX nephrotoxicity with an emphasis on oxidative stress, inflammation, and nuclear factor (erythroid-derived 2)-like 2/heme oxygenase 1 (Nr...