Antiangiogenic therapy reverses the immunosuppressive breast cancer microenvironment

• Main Authors: Wuzhen Chen (Author), Lesang Shen (Author), Jingxin Jiang (Author), Leyi Zhang (Author), Zhigang Zhang (Author), Jun Pan (Author), Chao Ni (Author), Zhigang Chen (Author)
• Format: Book
• Published: BMC, 2021-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Tumor angiogenesis induces local hypoxia and recruits immunosuppressive cells, whereas hypoxia subsequently promotes tumor angiogenesis. Immunotherapy efficacy depends on the accumulation and activity of tumor-infiltrating immune cells (TIICs). Antangiogenic therapy could improve local perf...