IL-1β Genetic Polimorphism in Menopause Women as Periodontal Disease Risk Factor

• Main Authors: Justine Tanjaya (Author), Elza Ibrahim Auerkari (Author)
• Format: Book
• Published: Faculty of Dentistry, Universitas Indonesia, 2013-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.
• Notes: 1693-9697; 2355-4800; 10.14693/jdi.v18i1.52
• Keywords: genetic polymorphism; menopause; periodontal disease; Dentistry; RK1-715
• Source: Journal of Dentistry Indonesia, Vol 18, Iss 1, Pp 1-5 (2013)

<p>Periodontal disease is a disease with multifactorial etiology that can occur in postmenopausal women. <strong>Objective:</strong> This research aims to know the description of the genetic polymorphism of IL-1β in postmenopausal women in Indonesia as a risk factor for periodontal disease. <strong>Methods:</strong> This study is a descriptive study on 55 biological stored amples. Sample's extracted DNA was analysed for polymorphisms IL-1β+3954 using PCR-RFLP method with Taqα1 restriction enzyme digests then the result was electroforized. Research results were analyzed using chi square test. <strong>Results: </strong>The genotype CC frequency was 85.7%, CT 14.3%, and TT was absent in normal people. CC 86.5%, CT 8.3%, and TT did not exist in people who have periodontal disease. <strong>Conclusion: </strong>Genetic polymorphisms IL-1β in Indonesia's postmenopausal women is not a risk factor for periodontal disease</p><p>DOI: 10.14693/jdi.v18i1.52</p>