Generic semi-automated radiofluorination strategy for single domain antibodies: [18F]FB-labelled single domain antibodies for PET imaging of fibroblast activation protein-α or folate receptor-α overexpression in cancer

• Main Authors: Herlinde Dierick (Author), Laurent Navarro (Author), Hannelore Ceuppens (Author), Thomas Ertveldt (Author), Ana Rita Pombo Antunes (Author), Marleen Keyaerts (Author), Nick Devoogdt (Author), Karine Breckpot (Author), Matthias D'Huyvetter (Author), Tony Lahoutte (Author), Vicky Caveliers (Author), Jessica Bridoux (Author)
• Format: Book
• Published: SpringerOpen, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Radiofluorination of single domain antibodies (sdAbs) via N-succinimidyl-4-[18F]fluorobenzoate ([18F]SFB) has shown to be a promising strategy in the development of sdAb-based PET tracers. While automation of the prosthetic group (PG) [18F]SFB production, has been successfully re...