Nrf2/ARE Signaling Directly Regulates SOX9 to Potentially Alter Age-Dependent Cartilage Degeneration

• Main Authors: Yusuke Kubo (Author), Rainer Beckmann (Author), Athanassios Fragoulis (Author), Claudius Conrads (Author), Prathyusha Pavanram (Author), Sven Nebelung (Author), Michael Wolf (Author), Christoph Jan Wruck (Author), Holger Jahr (Author), Thomas Pufe (Author)
• Format: Book
• Published: MDPI AG, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress is implicated in osteoarthritis, and nuclear factor erythroid 2-related factor 2 (Nrf2)/antioxidant response element (ARE) pathway maintains redox homeostasis. We investigated whether Nrf2/ARE signaling controls SOX9. SOX9 expression in human C-28/I2 chondrocytes was measured by RT-...