3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors

• প্রধান লেখক: Aleksandrs Pustenko (লেখক), Dmitrijs Stepanovs (লেখক), Raivis Žalubovskis (লেখক), Daniela Vullo (লেখক), Andris Kazaks (লেখক), Janis Leitans (লেখক), Kaspars Tars (লেখক), Claudiu T. Supuran (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

A new chemotype with carbonic anhydrase (CA, EC 4.2.1.1) inhibitory action has been discovered, the homo-sulfocoumarins (3H-1,2-benzoxathiepine 2,2-dioxides) which have been designed considering the (sulfo)coumarins as lead molecules. An original synthetic strategy of a panel of such derivatives led...