3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors

• Главные авторы: Aleksandrs Pustenko (Автор), Dmitrijs Stepanovs (Автор), Raivis Žalubovskis (Автор), Daniela Vullo (Автор), Andris Kazaks (Автор), Janis Leitans (Автор), Kaspars Tars (Автор), Claudiu T. Supuran (Автор)
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• Опубликовано: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Предметы: article
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A new chemotype with carbonic anhydrase (CA, EC 4.2.1.1) inhibitory action has been discovered, the homo-sulfocoumarins (3H-1,2-benzoxathiepine 2,2-dioxides) which have been designed considering the (sulfo)coumarins as lead molecules. An original synthetic strategy of a panel of such derivatives led...