3H-1,2-benzoxathiepine 2,2-dioxides: a new class of isoform-selective carbonic anhydrase inhibitors

• Κύριοι συγγραφείς: Aleksandrs Pustenko (Συγγραφέας), Dmitrijs Stepanovs (Συγγραφέας), Raivis Žalubovskis (Συγγραφέας), Daniela Vullo (Συγγραφέας), Andris Kazaks (Συγγραφέας), Janis Leitans (Συγγραφέας), Kaspars Tars (Συγγραφέας), Claudiu T. Supuran (Συγγραφέας)
• Μορφή: Βιβλίο
• Έκδοση: Taylor & Francis Group, 2017-01-01T00:00:00Z.
• Θέματα: article
• Διαθέσιμο Online: Connect to this object online.

A new chemotype with carbonic anhydrase (CA, EC 4.2.1.1) inhibitory action has been discovered, the homo-sulfocoumarins (3H-1,2-benzoxathiepine 2,2-dioxides) which have been designed considering the (sulfo)coumarins as lead molecules. An original synthetic strategy of a panel of such derivatives led...