Alteration of Inflammatory Mediators in the Upper and Lower Airways under Chronic Intermittent Hypoxia: Preliminary Animal Study

• Main Authors: Eun Jung Lee (Author), Woon Heo (Author), Joo Young Kim (Author), Hyungchul Kim (Author), Min Jung Kang (Author), Bo Ra Kim (Author), Ji Hyun Kim (Author), Do Yang Park (Author), Chang-Hoon Kim (Author), Joo-Heon Yoon (Author), Hyung-Ju Cho (Author)
• Format: Book
• Published: Hindawi Limited, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Purpose. We hypothesized that CIH may affect the upper airway immune system and aimed to verify whether CIH can induce airway inflammation in a murine obstructive sleep apnea (OSA) model. Methods. C57BL6 male mice were exposed to intermittent hypoxia (CIH group; 5 ~ 21% FiO2, 120 sec cycles, 12 h/d,...