Novel naphthalene-based inhibitors of Trypanosoma brucei RNA editing ligase 1.

• Main Authors: Jacob D Durrant (Author), Laurence Hall (Author), Robert V Swift (Author), Melissa Landon (Author), Achim Schnaufer (Author), Rommie E Amaro (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2010-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Neglected tropical diseases, including diseases caused by trypanosomatid parasites such as Trypanosoma brucei, cost tens of millions of disability-adjusted life-years annually. As the current treatments for African trypanosomiasis and other similar infections are limited, new therapeutics are urgent...