Tissue Pharmacokinetic Properties and Bystander Potential of Hypoxia-Activated Prodrug CP-506 by Agent-Based Modelling

• Main Authors: Victoria Jackson-Patel (Author), Emily Liu (Author), Matthew R. Bull (Author), Amir Ashoorzadeh (Author), Gib Bogle (Author), Anna Wolfram (Author), Kevin O. Hicks (Author), Jeff B. Smaill (Author), Adam V. Patterson (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hypoxia-activated prodrugs are bioactivated in oxygen-deficient tumour regions and represent a novel strategy to exploit this pharmacological sanctuary for therapeutic gain. The approach relies on the selective metabolism of the prodrug under pathological hypoxia to generate active metabolites with...