CD4+CD25+ regulatory cells contribute to the regulation of colonic Th2 granulomatous pathology caused by schistosome infection.

• Main Authors: Joseph D Turner (Author), Gavin R Jenkins (Author), Karen G Hogg (Author), Sarah A Aynsley (Author), Ross A Paveley (Author), Peter C Cook (Author), Mark C Coles (Author), Adrian P Mountford (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2011-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Eggs of the helminth Schistosoma mansoni accumulate in the colon following infection and generate Th2-biassed inflammatory granulomas which become down- modulated in size as the infection proceeds to chronicity. However, although CD4+CD25+FoxP3+ regulatory T cells (T(regs)) are known to suppress Th1...