CD4+CD25+ regulatory cells contribute to the regulation of colonic Th2 granulomatous pathology caused by schistosome infection.

• Autori principali: Joseph D Turner (Autore), Gavin R Jenkins (Autore), Karen G Hogg (Autore), Sarah A Aynsley (Autore), Ross A Paveley (Autore), Peter C Cook (Autore), Mark C Coles (Autore), Adrian P Mountford (Autore)
• Natura: Libro
• Pubblicazione: Public Library of Science (PLoS), 2011-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Eggs of the helminth Schistosoma mansoni accumulate in the colon following infection and generate Th2-biassed inflammatory granulomas which become down- modulated in size as the infection proceeds to chronicity. However, although CD4+CD25+FoxP3+ regulatory T cells (T(regs)) are known to suppress Th1...