Glyoxalase System as a Therapeutic Target against Diabetic Retinopathy

• Main Authors: Gemma Aragonès (Author), Sheldon Rowan (Author), Sarah G Francisco (Author), Wenxin Yang (Author), Jasper Weinberg (Author), Allen Taylor (Author), Eloy Bejarano (Author)
• Format: Book
• Published: MDPI AG, 2020-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Hyperglycemia, a defining characteristic of diabetes, combined with oxidative stress, results in the formation of advanced glycation end products (AGEs). AGEs are toxic compounds that have adverse effects on many tissues including the retina and lens. AGEs promote the formation of reactive oxygen sp...