Splice-Switching Antisense Oligonucleotides Reduce LRRK2 Kinase Activity in Human LRRK2 Transgenic Mice

• Main Authors: Joanna A. Korecka (Author), Ria Thomas (Author), Anthony J. Hinrich (Author), Alyssa M. Moskites (Author), Zach K. Macbain (Author), Penelope J. Hallett (Author), Ole Isacson (Author), Michelle L. Hastings (Author)
• Format: Book
• Published: Elsevier, 2020-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Parkinson's disease (PD) is a progressive neurological disorder estimated to affect 7-10 million people worldwide. There is no treatment available that cures or slows the progression of PD. Elevated leucine-rich repeat kinase 2 (LRRK2) activity has been associated with genetic and sporadic form...