Intra-islet glucagon signalling regulates beta-cell connectivity, first-phase insulin secretion and glucose homoeostasis

• Main Authors: K. Suba (Author), Y. Patel (Author), A. Martin-Alonso (Author), B. Hansen (Author), X. Xu (Author), A. Roberts (Author), M. Norton (Author), P. Chung (Author), J. Shrewsbury (Author), R. Kwok (Author), V. Kalogianni (Author), S. Chen (Author), X. Liu (Author), K. Kalyviotis (Author), G.A. Rutter (Author), B. Jones (Author), J. Minnion (Author), B.M. Owen (Author), P. Pantazis (Author), W. Distaso (Author), D.J. Drucker (Author), T.M. Tan (Author), S.R. Bloom (Author), K.G. Murphy (Author), V. Salem (Author)
• Format: Book
• Published: Elsevier, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Type 2 diabetes (T2D) is characterised by the loss of first-phase insulin secretion. We studied mice with β-cell selective loss of the glucagon receptor (Gcgrfl/fl X Ins-1Cre), to investigate the role of intra-islet glucagon receptor (GCGR) signalling on pan-islet [Ca2+]I activity and ins...