In Silico and In Vitro Screening of Serine Racemase Agonist and In Vivo Efficacy on Alzheimer's Disease <i>Drosophila melanogaster</i>

• Main Authors: Chih-Hao Lu (Author), Hao-Teng Chang (Author), Lee-Fen Hsu (Author), Ming-Hsueh Lee (Author), Jack Cheng (Author), Dong Chuan Wu (Author), Wei-Yong Lin (Author)
• Format: Book
• Published: MDPI AG, 2023-02-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The NMDA receptor hypofunction has been implicated in schizophrenia, memory impairment, and Alzheimer's disease. Modulating the abundance of D-serine, a co-agonist of the NMDA receptor, is a strategy to treat symptoms of the NMDA receptor hypofunction. In contrast to D-amino acid oxidase (DAAO)...