Elevated SAA1 promotes the development of insulin resistance in ovarian granulosa cells in polycystic ovary syndrome

• Main Authors: Qinling Zhu (Author), Yue Yao (Author), Lizhen Xu (Author), Hasiximuke Wu (Author), Wangsheng Wang (Author), Yaqiong He (Author), Yuan Wang (Author), Yao Lu (Author), Jia Qi (Author), Ying Ding (Author), Xinyu Li (Author), Jiaan Huang (Author), Hanting Zhao (Author), Yanzhi Du (Author), Kang Sun (Author), Yun Sun (Author)
• Format: Book
• Published: BMC, 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Insulin resistance (IR) contributes to ovarian dysfunctions in polycystic ovarian syndrome (PCOS) patients. Serum amyloid A1 (SAA1) is an acute phase protein produced primarily by the liver in response to inflammation. In addition to its role in inflammation, SAA1 may participate...