Sialylation of EGFR by the ST6Gal-I sialyltransferase promotes EGFR activation and resistance to gefitinib-mediated cell death

• Main Authors: Colleen M. Britain (Author), Andrew T. Holdbrooks (Author), Joshua C. Anderson (Author), Christopher D. Willey (Author), Susan L. Bellis (Author)
• 格式: 图书
• 出版: BMC, 2018-02-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Abstract Background The ST6Gal-I sialyltransferase is upregulated in numerous cancers, and high expression of this enzyme correlates with poor patient prognosis in various malignancies, including ovarian cancer. Through its sialylation of a select cohort of cell surface receptors, ST6Gal-I modulates...