Membrane Lipid Reshaping Underlies Oxidative Stress Sensing by the Mitochondrial Proteins UCP1 and ANT1

• Main Authors: Olga Jovanović (Author), Ksenia Chekashkina (Author), Sanja Škulj (Author), Kristina Žuna (Author), Mario Vazdar (Author), Pavel V. Bashkirov (Author), Elena E. Pohl (Author)
• Format: Book
• Published: MDPI AG, 2022-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxidative stress and ROS are important players in the pathogenesis of numerous diseases. In addition to directly altering proteins, ROS also affects lipids with negative intrinsic curvature such as phosphatidylethanolamine (PE), producing PE adducts and lysolipids. The formation of PE adducts potent...