Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice

• Hlavní autoři: Robert H. Oakley (Autor), Matthew J. Campen (Autor), Michael L. Paffett (Autor), Xin Chen (Autor), Zhongjing Wang (Autor), Traci L. Parry (Autor), Carolyn Hillhouse (Autor), John A. Cidlowski (Autor), Monte S. Willis (Autor)
• Médium: Kniha
• Vydáno: BMC, 2018-09-01T00:00:00Z.
• Témata: article
• On-line přístup: Connect to this object online.

Abstract Background We recently identified a role for the muscle-specific ubiquitin ligase MuRF1 in right-sided heart failure secondary to pulmonary hypertension induced by chronic hypoxia (CH). MuRF1−/− mice exposed to CH are resistant to right ventricular (RV) dysfunction whereas MuRF1 Tg + mice e...