Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice

Muscle-specific regulation of right ventricular transcriptional responses to chronic hypoxia-induced hypertrophy by the muscle ring finger-1 (MuRF1) ubiquitin ligase in mice

Abstract Background We recently identified a role for the muscle-specific ubiquitin ligase MuRF1 in right-sided heart failure secondary to pulmonary hypertension induced by chronic hypoxia (CH). MuRF1−/− mice exposed to CH are resistant to right ventricular (RV) dysfunction whereas MuRF1 Tg + mice e...

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Main Authors: Robert H. Oakley (Author), Matthew J. Campen (Author), Michael L. Paffett (Author), Xin Chen (Author), Zhongjing Wang (Author), Traci L. Parry (Author), Carolyn Hillhouse (Author), John A. Cidlowski (Author), Monte S. Willis (Author)
Format: Book
Published: BMC, 2018-09-01T00:00:00Z.
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