FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques

• Main Authors: Joanna Zikos (Author), Gabriela M. Webb (Author), Helen L. Wu (Author), Jason S. Reed (Author), Jennifer Watanabe (Author), Jodie L. Usachenko (Author), Ala M. Shaqra (Author), Celia A. Schiffer (Author), Koen K. A. Van Rompay (Author), Jonah B. Sacha (Author), Diogo M. Magnani (Author)
• Format: Book
• Published: Taylor & Francis Group, 2024-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Prenatal administration of monoclonal antibodies (mAbs) is a strategy that could be exploited to prevent viral infections during pregnancy and early life. To reach protective levels in fetuses, mAbs must be transported across the placenta, a selective barrier that actively and specifically promotes...