Scaling approaches for the prediction of human clearance of LNA-i-mir-221: A retrospective validation

• Main Authors: Massimiliano Fonsi (Author), Jacques Fulbert (Author), Pierre-Andre Billat (Author), Mariamena Arbitrio (Author), Pierosandro Tagliaferri (Author), Pierfrancesco Tassone (Author), Maria Teresa Di Martino (Author)
• Format: Book
• Published: Elsevier, 2024-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

LNA-i-miR-221 is a novel microRNA(miRNA)-221 inhibitor designed for the treatment of human malignancies. It has recently undergone phase 1 clinical trial (P1CT) and early pharmacokinetics (PKs) data in cancer patients are now available. We previously used multiple allometric interspecies scaling met...