Evaluation of miR-15a, miR-16-1, ZAP-70, Ang-2, and Bcl-2 as potential prognostic biomarkers in chronic lymphocytic leukemia

• Main Authors: Tatiane Vieira Braga (Author), Fernanda Cristina Gontijo Evangelista (Author), Marie Gabriele Santiago (Author), Aline Lúcia Menezes Ferrão (Author), Tamara Dauare de Almeida (Author), Bárbara Lima da Fonseca Barbosa (Author), Sergio Schusterschitz da Silva Araujo (Author), Glaciano Nogueira Ribeiro (Author), Maria das Graças Carvalho (Author), Adriano de Paula Sabino (Author)
• Format: Book
• Published: Universidade de São Paulo, 2022-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Chronic lymphocytic leukemia (CLL) is a blood cancer characterized by the accumulation of clonal B-lymphocytes. This study evaluated the mRNA gene expression of miR-15a, miR-16- 1, ZAP-70, and Ang-2 by qPCR, as well as the plasma levels of Bcl-2 by Elisa immunoassay, in CLL patients and hea...