Identification of novel bacterial DNA gyrase inhibitors: An in silico study

• Үндсэн зохиолчид: Hamzeh Rahimi (Зохиогч), Ali Najafi (Зохиогч), Habib Eslami (Зохиогч), Babak Negahdari (Зохиогч), Mehrdad Moosazadeh Moghaddam (Зохиогч)
• Формат: Ном
• Хэвлэсэн: Wolters Kluwer Medknow Publications, 2016-01-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Owing to essential role in bacterial survival, DNA gyrase has been exploited as a validated drug target. However, rapidly emerging resistance to gyrase-targeted drugs such as widely utilized fluoroquinolones reveals the necessity to develop novel compounds with new mechanism of actions against this...