Cover Image

Identification of novel bacterial DNA gyrase inhibitors: An in silico study

Owing to essential role in bacterial survival, DNA gyrase has been exploited as a validated drug target. However, rapidly emerging resistance to gyrase-targeted drugs such as widely utilized fluoroquinolones reveals the necessity to develop novel compounds with new mechanism of actions against this...

Full description

Saved in:

Bibliographic Details
Main Authors:	Hamzeh Rahimi (Author), Ali Najafi (Author), Habib Eslami (Author), Babak Negahdari (Author), Mehrdad Moosazadeh Moghaddam (Author)
Format:	Book
Published:	Wolters Kluwer Medknow Publications, 2016-01-01T00:00:00Z.
Subjects:	article
Online Access:	Connect to this object online.
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Selective DNA Gyrase Inhibitors: Multi-Target in Silico Profiling with 3D-Pharmacophores
by: Tihomir Tomašič, et al.
Published: (2021)

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV
by: Scott Grossman, et al.
Published: (2023)

Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation
by: Martina Durcik, et al.
Published: (2020)

Exploring the Antimicrobial and Pharmacological Potential of NF22 as a Potent Inhibitor of <i>E. coli</i> DNA Gyrase: An In Vitro and In Silico Study
by: Samman Munir, et al.
Published: (2022)

Docking studies on novel analogs of quinolones against DNA gyrase of Escherichia coli
by: Cristian Davila, et al.
Published: (2018)

Design, Synthesis, and Antibacterial Screening of Some Novel Heteroaryl-Based Ciprofloxacin Derivatives as DNA Gyrase and Topoisomerase IV Inhibitors
by: Lamya H. Al-Wahaibi, et al.
Published: (2021)

Experimental and Molecular Docking Studies of Cyclic Diphenyl Phosphonates as DNA Gyrase Inhibitors for Fluoroquinolone-Resistant Pathogens
by: Neveen M. Saleh, et al.
Published: (2022)

In Silico Study of the Potential Inhibitory Effects on <i>Escherichia coli</i> DNA Gyrase of Some Hypothetical Fluoroquinolone-Tetracycline Hybrids
by: Ioana-Andreea Lungu, et al.
Published: (2024)

Detection of DNA Gyrase Mutation and Multidrug Efflux Pumps Hyperactivity in Ciprofloxacin Resistant Clinical Isolates of Pseudomonas aeruginosa
by: Abolghasem Tohidpour, et al.
Published: (2013)

Comprehensive review of DNA gyrase as enzymatic target for drug discovery and development
by: K. Rajakumari, et al.
Published: (2024)

In silico analysis of luteolin derivatives as antibacterial agents targeting DNA gyrase and CTX-M-15 extended-spectrum β-lactamase of Escherichia coli
by: Nuzul Wahyuning Diyah, et al.
Published: (2024)

Discovery of Benzopyrone-Based Candidates as Potential Antimicrobial and Photochemotherapeutic Agents through Inhibition of DNA Gyrase Enzyme B: Design, Synthesis, In Vitro and In Silico Evaluation
by: Akram Abd El-Haleem, et al.
Published: (2024)

DC-159a Shows Inhibitory Activity against DNA Gyrases of Mycobacterium leprae.
by: Tomoyuki Yamaguchi, et al.
Published: (2016)

Impact of amino acid substitutions in B subunit of DNA gyrase in Mycobacterium leprae on fluoroquinolone resistance.
by: Kazumasa Yokoyama, et al.
Published: (2012)

Design and synthesis of new 3-((7-chloroquinolin-4-yl)amino)thiazolidin-4-one analogs as Mycobacterium tuberculosis DNA gyrase inhibitors
by: Preeti S. Salve, et al.
Published: (2021)

s-Triazine Derivatives Functionalized with Alkylating 2-Chloroethylamine Fragments as Promising Antimicrobial Agents: Inhibition of Bacterial DNA Gyrases, Molecular Docking Studies, and Antibacterial and Antifungal Activity
by: Dawid Maliszewski, et al.
Published: (2023)

Sulfaguanidine Hybrid with Some New Pyridine-2-One Derivatives: Design, Synthesis, and Antimicrobial Activity against Multidrug-Resistant Bacteria as Dual DNA Gyrase and DHFR Inhibitors
by: Ahmed Ragab, et al.
Published: (2021)

Allicin, a natural antimicrobial defence substance from garlic, inhibits DNA gyrase activity in bacteria
by: Jana Reiter, et al.
Published: (2020)

Identification of a Novel Dual Inhibitor of Acetylcholinesterase and Butyrylcholinesterase: In Vitro and In Silico Studies
by: Raquel B. M. de Almeida, et al.
Published: (2023)

Discovery of N-quinazolinone-4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents
by: Wenjie Xue, et al.
Published: (2022)

In silico identification of EGFR-T790M inhibitors with novel scaffolds: start with extraction of common features
by: Xiang M, et al.
Published: (2013)

Characterization of Mutations in DNA Gyrase and Topoisomerase IV in Field Strains and In Vitro Selected Quinolone-Resistant <i>Mycoplasma hyorhinis</i> Mutants
by: Jun Li, et al.
Published: (2022)

Discovery of a Novel Mutation in DNA Gyrase and Changes in the Fluoroquinolone Resistance of <i>Helicobacter pylori</i> over a 14-Year Period: A Single Center Study in Korea
by: Su Yeon Rhie, et al.
Published: (2020)

In-silico identification of novel inhibitors for human Aurora kinase B form the ZINC database using molecular docking-based virtual screening
by: Ashraf Ahmed Ali Abdusalam
Published: (2022)

Novel Antibiotics Targeting Bacterial Replicative DNA Polymerases
by: Joana A. Santos, et al.
Published: (2020)

Fragment-Based Discovery of Inhibitors of the Bacterial DnaG-SSB Interaction
by: Zorik Chilingaryan, et al.
Published: (2018)

Identification of NAPRT Inhibitors with Anti-Cancer Properties by In Silico Drug Discovery
by: Moustafa S. Ghanem, et al.
Published: (2022)

In Silico Identification of Novel Inhibitors Targeting the Homodimeric Interface of Superoxide Dismutase from the Dental Pathogen <i>Streptococcus mutans</i>
by: Carmen Cerchia, et al.
Published: (2022)

Novel Pharmacological Inhibitors for Bacterial Protein Toxins
by: Holger Barth
Published: (2017)

In silico and in vitro screening of pyrrole-based Hydrazide-Hydrazones as novel acetylcholinesterase inhibitors
by: Emilio Mateev, et al.
Published: (2024)

Identification of 3-(piperazinylmethyl)benzofuran derivatives as novel type II CDK2 inhibitors: design, synthesis, biological evaluation, and in silico insights
by: Wagdy M. Eldehna, et al.
Published: (2022)

Identification of novel bacterial species in the blood of patients with neonatal sepsis
by: Yi Wu, et al.
Published: (2024)

Discovery of novel inhibitors of ghrelin O-acyltransferase enzyme: an in-silico approach
by: Faezeh Sadat Hosseini, et al.
Published: (2022)

Synthesis, kinetic studies and in-silico investigations of novel quinolinyl-iminothiazolines as alkaline phosphatase inhibitors
by: Muhammad Naeem Mustafa, et al.
Published: (2023)

First In Silico Screening of Insect Molecules for Identification of Novel Anti-Parasitic Compounds
by: Tom L. Gallinger, et al.
Published: (2022)

In silico-based identification of human α-enolase inhibitors to block cancer cell growth metabolically
by: Lung J, et al.
Published: (2017)

Identification of Novel Anthracycline Resistance Genes and Their Inhibitors
by: Onat Kadioglu, et al.
Published: (2021)

A review on in silico virtual screening methods in COVID-19 using anticancer drugs and other natural/chemical inhibitors
by: Babak Sokouti
Published: (2023)

Novel thiazolone-benzenesulphonamide inhibitors of human and bacterial carbonic anhydrases
by: Morteza Abdoli, et al.
Published: (2023)

Novel Bacterial Topoisomerase inhibitors (NBTIs) - A comprehensive review
by: Jigar Desai, et al.
Published: (2021)