Pharmacokinetic interactions of esaxerenone with amlodipine and digoxin in healthy Japanese subjects

• Main Authors: Yoshiaki Kirigaya (Author), Masanari Shiramoto (Author), Tomoko Ishizuka (Author), Hinako Uchimaru (Author), Shin Irie (Author), Manabu Kato (Author), Takako Shimizu (Author), Takafumi Nakatsu (Author), Yasuhiro Nishikawa (Author), Hitoshi Ishizuka (Author)
• Format: Book
• Published: BMC, 2020-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background To investigate the effects of coadministration of esaxerenone with amlodipine on the pharmacokinetics (PK) of each drug, and of esaxerenone on the PK of digoxin. Methods In three open-label, single-sequence, crossover studies, healthy Japanese males received single oral doses of...