Anionic Complex with Efficient Expression and Good Safety Profile for mRNA Delivery

• Main Authors: Eri Hamada (Author), Tomoaki Kurosaki (Author), Junya Hashizume (Author), Hitomi Harasawa (Author), Hiroo Nakagawa (Author), Tadahiro Nakamura (Author), Yukinobu Kodama (Author), Hitoshi Sasaki (Author)
• Format: Book
• Published: MDPI AG, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

We previously found that a complex comprising plasmid DNA (pDNA), polyethylenimine (PEI), and γ-polyglutamic acid (γ-PGA) had high transgene efficiency without cytotoxicity in vitro and in vivo. However, messenger RNA (mRNA) remains an attractive alternative to pDNA. In this study, we developed a sa...