The Multifaceted Histidine-Based Carriers for Nucleic Acid Delivery: Advances and Challenges

• Main Authors: Jiaxi He (Author), Songhui Xu (Author), A. James Mixson (Author)
• 格式: 圖書
• 出版: MDPI AG, 2020-08-01T00:00:00Z.
• 主題: article
• 在線閱讀: Connect to this object online.

Histidines incorporated into carriers of nucleic acids may enhance the extracellular stability of the nanoparticle, yet aid in the intracellular disruption of the nanoparticle, enabling the release of the nucleic acid. Moreover, protonation of histidines in the endosomes may result in endosomal swel...