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Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction

Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses suggest the presence of a dynamic equilibrium betwee...

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Main Authors: Masakazu Sugishima (Author), Junichi Taira (Author), Tatsuya Sagara (Author), Ryota Nakao (Author), Hideaki Sato (Author), Masato Noguchi (Author), Keiichi Fukuyama (Author), Ken Yamamoto (Author), Takuo Yasunaga (Author), Hiroshi Sakamoto (Author)
Format: Book
Published: MDPI AG, 2020-07-01T00:00:00Z.
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