Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction

• المؤلفون الرئيسيون: Masakazu Sugishima (مؤلف), Junichi Taira (مؤلف), Tatsuya Sagara (مؤلف), Ryota Nakao (مؤلف), Hideaki Sato (مؤلف), Masato Noguchi (مؤلف), Keiichi Fukuyama (مؤلف), Ken Yamamoto (مؤلف), Takuo Yasunaga (مؤلف), Hiroshi Sakamoto (مؤلف)
• التنسيق: كتاب
• منشور في: MDPI AG, 2020-07-01T00:00:00Z.
• الموضوعات: article
• الوصول للمادة أونلاين: Connect to this object online.

Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses suggest the presence of a dynamic equilibrium betwee...