Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction

• প্রধান লেখক: Masakazu Sugishima (লেখক), Junichi Taira (লেখক), Tatsuya Sagara (লেখক), Ryota Nakao (লেখক), Hideaki Sato (লেখক), Masato Noguchi (লেখক), Keiichi Fukuyama (লেখক), Ken Yamamoto (লেখক), Takuo Yasunaga (লেখক), Hiroshi Sakamoto (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: MDPI AG, 2020-07-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses suggest the presence of a dynamic equilibrium betwee...