Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction

• Prif Awduron: Masakazu Sugishima (Awdur), Junichi Taira (Awdur), Tatsuya Sagara (Awdur), Ryota Nakao (Awdur), Hideaki Sato (Awdur), Masato Noguchi (Awdur), Keiichi Fukuyama (Awdur), Ken Yamamoto (Awdur), Takuo Yasunaga (Awdur), Hiroshi Sakamoto (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2020-07-01T00:00:00Z.
• Pynciau: article
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Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses suggest the presence of a dynamic equilibrium betwee...