Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction

• Autores principales: Masakazu Sugishima (Autor), Junichi Taira (Autor), Tatsuya Sagara (Autor), Ryota Nakao (Autor), Hideaki Sato (Autor), Masato Noguchi (Autor), Keiichi Fukuyama (Autor), Ken Yamamoto (Autor), Takuo Yasunaga (Autor), Hiroshi Sakamoto (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2020-07-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses suggest the presence of a dynamic equilibrium betwee...