Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction

• Egile Nagusiak: Masakazu Sugishima (Egilea), Junichi Taira (Egilea), Tatsuya Sagara (Egilea), Ryota Nakao (Egilea), Hideaki Sato (Egilea), Masato Noguchi (Egilea), Keiichi Fukuyama (Egilea), Ken Yamamoto (Egilea), Takuo Yasunaga (Egilea), Hiroshi Sakamoto (Egilea)
• Formatua: Liburua
• Argitaratua: MDPI AG, 2020-07-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses suggest the presence of a dynamic equilibrium betwee...