Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction

• मुख्य लेखकों: Masakazu Sugishima (लेखक), Junichi Taira (लेखक), Tatsuya Sagara (लेखक), Ryota Nakao (लेखक), Hideaki Sato (लेखक), Masato Noguchi (लेखक), Keiichi Fukuyama (लेखक), Ken Yamamoto (लेखक), Takuo Yasunaga (लेखक), Hiroshi Sakamoto (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: MDPI AG, 2020-07-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses suggest the presence of a dynamic equilibrium betwee...