Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction

• Autori principali: Masakazu Sugishima (Autore), Junichi Taira (Autore), Tatsuya Sagara (Autore), Ryota Nakao (Autore), Hideaki Sato (Autore), Masato Noguchi (Autore), Keiichi Fukuyama (Autore), Ken Yamamoto (Autore), Takuo Yasunaga (Autore), Hiroshi Sakamoto (Autore)
• Natura: Libro
• Pubblicazione: MDPI AG, 2020-07-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses suggest the presence of a dynamic equilibrium betwee...