Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction

• 主要な著者: Masakazu Sugishima (著者), Junichi Taira (著者), Tatsuya Sagara (著者), Ryota Nakao (著者), Hideaki Sato (著者), Masato Noguchi (著者), Keiichi Fukuyama (著者), Ken Yamamoto (著者), Takuo Yasunaga (著者), Hiroshi Sakamoto (著者)
• フォーマット: 図書
• 出版事項: MDPI AG, 2020-07-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses suggest the presence of a dynamic equilibrium betwee...