Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction

• Váldodahkkit: Masakazu Sugishima (Dahkki), Junichi Taira (Dahkki), Tatsuya Sagara (Dahkki), Ryota Nakao (Dahkki), Hideaki Sato (Dahkki), Masato Noguchi (Dahkki), Keiichi Fukuyama (Dahkki), Ken Yamamoto (Dahkki), Takuo Yasunaga (Dahkki), Hiroshi Sakamoto (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: MDPI AG, 2020-07-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses suggest the presence of a dynamic equilibrium betwee...