Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction

• Asıl Yazarlar: Masakazu Sugishima (Yazar), Junichi Taira (Yazar), Tatsuya Sagara (Yazar), Ryota Nakao (Yazar), Hideaki Sato (Yazar), Masato Noguchi (Yazar), Keiichi Fukuyama (Yazar), Ken Yamamoto (Yazar), Takuo Yasunaga (Yazar), Hiroshi Sakamoto (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: MDPI AG, 2020-07-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses suggest the presence of a dynamic equilibrium betwee...