Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction

• Автори: Masakazu Sugishima (Автор), Junichi Taira (Автор), Tatsuya Sagara (Автор), Ryota Nakao (Автор), Hideaki Sato (Автор), Masato Noguchi (Автор), Keiichi Fukuyama (Автор), Ken Yamamoto (Автор), Takuo Yasunaga (Автор), Hiroshi Sakamoto (Автор)
• Формат: Книга
• Опубліковано: MDPI AG, 2020-07-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Heme oxygenase (HO) catalyzes heme degradation using electrons supplied by NADPH-cytochrome P450 oxidoreductase (CPR). Electrons from NADPH flow first to FAD, then to FMN, and finally to the heme in the redox partner. Previous biophysical analyses suggest the presence of a dynamic equilibrium betwee...