Novel hyaluronic acid oligosaccharide-loaded and CD44v6-targeting oxaliplatin nanoparticles for the treatment of colorectal cancer

• Main Authors: Wenlong Du (Author), Xiaoping Yang (Author), Shenfu He (Author), Jia Wang (Author), Yuanxian Guo (Author), Bangguo Kou (Author), Yongjie Jiang (Author), Pan Bian (Author), Bingtai Li (Author), Lanning Yin (Author)
• Format: Book
• Published: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Oxaliplatin resistance is one of the main causes of failed colorectal cancer treatment, followed by recurrence and metastasis. In this study, we found that colorectal cancer cells secrete a high level of hyaluronic acid (HA), which interacts with its receptor CD44v6 to mediate colorectal cancer resi...