Novel hyaluronic acid oligosaccharide-loaded and CD44v6-targeting oxaliplatin nanoparticles for the treatment of colorectal cancer

• Главные авторы: Wenlong Du (Автор), Xiaoping Yang (Автор), Shenfu He (Автор), Jia Wang (Автор), Yuanxian Guo (Автор), Bangguo Kou (Автор), Yongjie Jiang (Автор), Pan Bian (Автор), Bingtai Li (Автор), Lanning Yin (Автор)
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• Опубликовано: Taylor & Francis Group, 2021-01-01T00:00:00Z.
• Предметы: article
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Oxaliplatin resistance is one of the main causes of failed colorectal cancer treatment, followed by recurrence and metastasis. In this study, we found that colorectal cancer cells secrete a high level of hyaluronic acid (HA), which interacts with its receptor CD44v6 to mediate colorectal cancer resi...