Novel Compounds Synergize With Venetoclax to Target KMT2A-Rearranged Pediatric Acute Myeloid Leukemia

• Main Authors: Claudia Tregnago (Author), Maddalena Benetton (Author), Ambra Da Ros (Author), Giulia Borella (Author), Giorgia Longo (Author), Katia Polato (Author), Samuela Francescato (Author), Alessandra Biffi (Author), Martina Pigazzi (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

In pediatric acute myeloid leukemia (AML), fusions involving lysine methyltransferase 2A (KMT2A) are considered hallmarks of aggressive AML, for whom the development of targeted specific therapeutic agents to ameliorate classic chemotherapy and obtain a complete eradication of disease is urgent. In...