Mixed PEGylated surfactant modifying system decrease the accelerated blood clearance phenomenon of nanoemulsions in rats

• Main Authors: Yuqing Su (Author), Wenya Tang (Author), Yanzhi Song (Author), Chunling Wang (Author), Qingjing Tian (Author), Xuling Wang (Author), Jingjing Quan (Author), Buoqun Li (Author), Shaoning Wang (Author), Yihui Deng (Author)
• Format: Book
• Published: Elsevier, 2017-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The accelerated blood clearance (ABC) phenomenon which is induced by repeated injection of poly (ethylene glycol) (PEG)-coated colloidal carriers gives clinical challenge to the promising drug delivery system. It is necessary to decrease this unexpected immunological response. A novel 4-arm poly (et...