Pharmacokinetics and Pharmacodynamics Estimation of Eculizumab in a 2-Year-Old Girl With Atypical Hemolytic Uremic Syndrome: A Case Report With 4-Year Follow-Up

• Main Authors: Ken Saida (Author), Tsuyoshi Fukuda (Author), Kana Mizuno (Author), Masao Ogura (Author), Koichi Kamei (Author), Shuichi Ito (Author)
• 格式: 图书
• 出版: Frontiers Media S.A., 2019-12-01T00:00:00Z.
• 主题: article
• 在线阅读: Connect to this object online.

Background: Eculizumab has dramatically changed poor outcomes of complement-mediated atypical hemolytic uremic syndrome (aHUS) as first-line treatment. Discontinuation of eculizumab remains challenging, and doctor's visits every 2 weeks for intravenous injection because of standard dosing proto...