Melt Amorphisation of Orlistat with Mesoporous Silica Using a Supercritical Carbon Dioxide: Effects of Pressure, Temperature, and Drug Loading Ratio and Comparison with Other Conventional Amorphisation Methods

• Main Authors: Heejun Park (Author), Kwang-Ho Cha (Author), Seung Hyeon Hong (Author), Sharif Md Abuzar (Author), Eun-Sol Ha (Author), Jeong-Soo Kim (Author), Min-Soo Kim (Author), Sung-Joo Hwang (Author)
• Format: Book
• Published: MDPI AG, 2020-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The aim of this work was to develop an amorphous orlistat-loaded mesoporus silica formulation using the melt-amorphisation by supercritical fluid (MA-SCF) and to investigate the effects of pressure and temperature on the pharmaceutical properties of the developed formulation. In addition, the effect...