Melt Amorphisation of Orlistat with Mesoporous Silica Using a Supercritical Carbon Dioxide: Effects of Pressure, Temperature, and Drug Loading Ratio and Comparison with Other Conventional Amorphisation Methods

• Prif Awduron: Heejun Park (Awdur), Kwang-Ho Cha (Awdur), Seung Hyeon Hong (Awdur), Sharif Md Abuzar (Awdur), Eun-Sol Ha (Awdur), Jeong-Soo Kim (Awdur), Min-Soo Kim (Awdur), Sung-Joo Hwang (Awdur)
• Fformat: Llyfr
• Cyhoeddwyd: MDPI AG, 2020-04-01T00:00:00Z.
• Pynciau: article
• Mynediad Ar-lein: Connect to this object online.

The aim of this work was to develop an amorphous orlistat-loaded mesoporus silica formulation using the melt-amorphisation by supercritical fluid (MA-SCF) and to investigate the effects of pressure and temperature on the pharmaceutical properties of the developed formulation. In addition, the effect...