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Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in Psoriasis

Psoriasis is a chronic inflammatory skin disease where the altered regulation in angiogenesis, inflammation, and proliferation of keratinocytes are the possible causes of the disease, and the transcription factor "hypoxia-inducible factor 1-alpha" (HIF-1α) is involved in the homeostasis of...

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Main Authors: Azael Torales-Cardeña (Author), Isaí Martínez-Torres (Author), Sandra Rodríguez-Martínez (Author), Fernando Gómez-Chávez (Author), Juan C. Cancino-Díaz (Author), Ernesto A. Vázquez-Sánchez (Author), Mario E. Cancino-Díaz (Author)
Format: Book
Published: Hindawi Limited, 2015-01-01T00:00:00Z.
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Summary:Psoriasis is a chronic inflammatory skin disease where the altered regulation in angiogenesis, inflammation, and proliferation of keratinocytes are the possible causes of the disease, and the transcription factor "hypoxia-inducible factor 1-alpha" (HIF-1α) is involved in the homeostasis of these three biological phenomena. In this review, the role of HIF-1α in the cross talk between the cytokines and cells of the immunological system involved in the pathogenesis of psoriasis is discussed.
Item Description:0962-9351
1466-1861
10.1155/2015/607363

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