Cross Talk between Proliferative, Angiogenic, and Cellular Mechanisms Orchestred by HIF-1α in Psoriasis

• Autori principali: Azael Torales-Cardeña (Autore), Isaí Martínez-Torres (Autore), Sandra Rodríguez-Martínez (Autore), Fernando Gómez-Chávez (Autore), Juan C. Cancino-Díaz (Autore), Ernesto A. Vázquez-Sánchez (Autore), Mario E. Cancino-Díaz (Autore)
• Natura: Libro
• Pubblicazione: Hindawi Limited, 2015-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Riassunto

Psoriasis is a chronic inflammatory skin disease where the altered regulation in angiogenesis, inflammation, and proliferation of keratinocytes are the possible causes of the disease, and the transcription factor "hypoxia-inducible factor 1-alpha" (HIF-1α) is involved in the homeostasis of these three biological phenomena. In this review, the role of HIF-1α in the cross talk between the cytokines and cells of the immunological system involved in the pathogenesis of psoriasis is discussed.

Descrizione del documento

0962-9351
1466-1861
10.1155/2015/607363