Structural variants and modifications of hammerhead ribozymes targeting influenza A virus conserved structural motifs

• Main Authors: Tomasz Czapik (Author), Julita Piasecka (Author), Ryszard Kierzek (Author), Elzbieta Kierzek (Author)
• Formato: Livro
• Publicado em: Elsevier, 2022-09-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The naturally occurring structure and biological functions of RNA are correlated, which includes hammerhead ribozymes. We proposed new variants of hammerhead ribozymes targeting conserved structural motifs of segment 5 of influenza A virus (IAV) (+)RNA. The variants carry structural and chemical mod...